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Anti-EGFR Binding Nanobody Delivery System to Improve the Diagnosis and Treatment of Solid Tumours

[ Vol. 15 , Issue. 3 ]

Author(s):

Long Wang, Gengyuan Zhang, Long Qin, Huili Ye, Yan Wang, Bo Long and Zuoyi Jiao*   Pages 200 - 211 ( 12 )

Abstract:


Background: Epidermal Growth Factor Receptor (EGFR) and members of its homologous protein family mediate transmembrane signal transduction by binding to a specific ligand, which leads to regulated cell growth, differentiation, proliferation and metastasis. With the development and application of Genetically Engineered Antibodies (GEAs), Nanobodies (Nbs) constitute a new research hot spot in many diseases. A Nb is characterized by its low molecular weight, deep tissue penetration, good solubility and high antigen-binding affinity, the anti-EGFR Nbs are of significance for the diagnosis and treatment of EGFR-positive tumours.

Objective: This review aims to provide a comprehensive overview of the information about the molecular structure of EGFR and its transmembrane signal transduction mechanism, and discuss the anti-EGFR-Nbs influence on the diagnosis and treatment of solid tumours.

Methods: Data were obtained from PubMed, Embase and Web of Science. All patents are searched from the following websites: the World Intellectual Property Organization (WIPO®), the United States Patent Trademark Office (USPTO®) and Google Patents.

Results: EGFR is a key target for regulating transmembrane signaling. The anti-EGFR-Nbs for targeted drugs could effectively improve the diagnosis and treatment of solid tumours.

Conclusion: EGFR plays a role in transmembrane signal transduction. The Nbs, especially anti- EGFR-Nbs, have shown effectiveness in the diagnosis and treatment of solid tumours. How to increase the affinity of Nb and reduce its immunogenicity remain a great challenge.

Keywords:

Diagnosis and treatment, EGFR, molecular structure, nanobody, patent, solid tumor.

Affiliation:

The First Department of General Surgery, Lanzhou University Second Hospital, Lanzhou 730000, Gansu Province, The Cuiying Center, Lanzhou University Second Hospital, Lanzhou 730000, Gansu, The Cuiying Center, Lanzhou University Second Hospital, Lanzhou 730000, Gansu, The Cuiying Center, Lanzhou University Second Hospital, Lanzhou 730000, Gansu, The Cuiying Center, Lanzhou University Second Hospital, Lanzhou 730000, Gansu, The First Department of General Surgery, Lanzhou University Second Hospital, Lanzhou 730000, Gansu Province, The First Department of General Surgery, Lanzhou University Second Hospital, Lanzhou 730000, Gansu Province



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