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RNA Splicing: Basic Aspects Underlie Antitumor Targeting

[ Vol. 15 , Issue. 4 ]

Author(s):

Alzahraa A.M. Fergany* and Victor V. Tatarskiy   Pages 293 - 305 ( 13 )

Abstract:


Background: RNA splicing, a fundamental step in gene expression, is aimed at intron removal and ordering of exons to form the protein’s reading frame.

Objective: This review is focused on the role of RNA splicing in cancer biology; the splicing abnormalities that lead to tumor progression emerge as targets for therapeutic intervention.

Methods: We discuss the role of aberrant mRNA splicing in carcinogenesis and drug response.

Results and Conclusion: Pharmacological modulation of RNA splicing sets the stage for treatment approaches in situations where mRNA splicing is a clinically meaningful mechanism of the disease.

Keywords:

Cancer, molecular drug targets, RNA splicing, therapy, protein kinase inhibitors.

Affiliation:

Department of Occupational and Environmental Health, Graduate School of Pharmaceutical Science, Tokyo University of Science, Chiba, Institute of Gene Biology, Russian Academy of Sciences, Moscow



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