Submit Manuscript  

Article Details


Expression and Clinical Significance of Microtubule-Actin Cross-Linking Factor 1 in Serous Ovarian Cancer

[ Vol. 16 , Issue. 1 ]

Author(s):

Longyang Liu, Ke Hu, Zhaoyang Zeng, Caiqiu Xu, Jin Lv, Zhongqiu Lin and Bin Wen*   Pages 66 - 72 ( 7 )

Abstract:


Background: Ovarian Cancer (OC) remains the first leading cause of gynecologic malignancy. The survival rate from Serous Ovarian Cancer (SOC) is very low, and the present prognostic predictors of SOC are not very sensitive or specific.

Objective: The present study aimed to investigate Microtubule-Actin Cross-Linking Factor 1 (MACF1) expression in SOC tissues (including paraffin-embedded and fresh tissues) and to assess its expression and significant value in patients with SOC.

Methods: A total of 18 fresh SOC tissues and their paired paratumor tissues were performed with reverse-transcription quantitative PCR analysis to detect MACF1 mRNA expression. Moreover, 175 paraffin-embedded SOC tissues and 41 paratumor tissues were assessed for MACF1 expression using immunohistochemistry.

Results: The mRNA and protein expression of MACF1, both were higher in cancer tissues than that in paratumor tissues, and the high expression of MACF1 was associated with shorter Recurrence Free Survival (RFS) and Overall Survival (OS) in patients with SOC. Furthermore, multivariate regression analysis showed that high MACF1 expression was an independent poor survival predictor of patients with SOC.

Conclusion: MACF1 is upregulated in SOC, and it may be used as a useful prognostic biomarker in SOC.

Keywords:

Microtubule-actin cross-linking factor 1, ovarian cancer, overall survival, prognosis, recurrence-free survival, serous ovarian cancer.

Affiliation:

Cancer Center, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, 13 Shiliugang ST, Guangzhou 510315, Department of Gynecology, Guangdong Women and Children Hospital, Guangzhou 511442, Department of Gynecology, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, 13 Shiliugang ST, Guangzhou 510315, Department of Obstetrics and Gynecology, Third Affiliated Hospital, Southern Medical University, Guangzhou 510630, Cancer Center, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, 13 Shiliugang ST, Guangzhou 510315, Department of Gynecology Oncology, the Memorial Hospital of Sun Yat-sen University, Guangzhou 510000, Department of Gynecology, Guangdong Women and Children Hospital, Guangzhou 511442



Read Full-Text article